Genetic Variants Tied to Cirrhosis Risk and Influence of Alcohol, Obesity

Recent research has identified 12 genetic variants, including 7 newly discovered ones, that are associated with an increased risk of cirrhosis. These findings emerged from a multi-trait genome-wide association study combining cirrhosis cases and alanine aminotransferase levels across several large cohorts, with validation in additional studies.

Alcohol’s Dual Impact: Balancing Risks and Benefits in Obesity and Heart Health

Recent research highlights the complex relationship between alcohol consumption, obesity, liver disease, and cardiovascular risk. Excessive alcohol intake is well-known for its harmful effects, including contributions to obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular issues.

TNF-α’s Role in Immunometabolism

Immune and metabolic responses are tightly integrated to maintain balance in organisms, with tumor necrosis factor-alpha (TNF-α) playing a key role in both processes.

Meeting the Challenge of MASH

Worldwide, MASH is increasing, and this is a challenge for patients and clinicians. Addressing this challenge is the development of evidence-based recommendations for the assessment and management of patients who live with MASLD and MASH.